Restoration of the striatal circuitry: from developmental aspects toward clinical applications

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Marie-Christin Pauly1*, Tobias Piroth2, Máté Döbrössy1 and Guido Nikkhah1
  • 1Division of Stereotactic Neurosurgery, Department of General Neurosurgery, University Freiburg – Medical Center, Freiburg im Breisgau, Germany
  • 2Department of Neurology, University Freiburg – Medical Center, Freiburg im Breisgau, Germany

 

Abstract

In the basal ganglia circuitry, the striatum is a highly complex structure coordinating motor and cognitive functions and it is severely affected in Huntington’s disease (HD) patients. Transplantation of fetal ganglionic eminence (GE) derived precursor cells aims to restore neural circuitry in the degenerated striatum of HD patients. Pre-clinical transplantation in genetic and lesion HD animal models has increased our knowledge of graft vs. host interactions, and clinical studies have been shown to successfully reduce motor and cognitive effects caused by the disease. Investigating the molecular mechanisms of striatal neurogenesis is a key research target, since novel strategies aim on generating striatal neurons by differentiating embryonic stem cells or by reprogramming somatic cells as alternative cell source for neural transplantation.

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Source: Frontiers  Cellular Neuroscience


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