On January 7, 2013 on “Help 4 HD – The HD View” I openly invited Dr. Paul Muchowski for
an interview.  On January 10, 2013, I received an email from him with the following address
to the community.  I wish to thank Dr. Muchowski for contacting me 
directly.  Below is his
address to the community in its entirety.

To Members of the Community (from Dr. Paul Muchowski):

 The purpose of this letter is to express my sincere remorse and apologies to the community. Recently, the Health
and Human Services (HHS) agency, which oversees the
 Office of Research Integrity (ORI), concluded that I was
responsible for incidents of
 scientific misconduct. Based on extensive feedback and questions I have received from
the community and the paucity of media information provided, I feel that it may be
 helpful to try to clarify some
questions publicly.

The ORI found that I “falsely reported research experiments when the results did not exist at the time the grant
applications were submitted.” In these instances, I stated that
 the experiments had, in fact, been performed prior to
their completion. Based on previous
 experience with such experiments, I believed that I could perform these
experiments by
 the time that my grant would be reviewed. These experiments were successfully completed or found
to be non-essential for the research program, but only after the grants
 were reviewed.

Although the experiments in question were not critical for determining the fate of the grant applications, I now
know with conviction and remorse to only include the data I
 have at hand and have checked myself. I realize that any
shortcuts in drafting the grant
 applications are wrong and are not acceptable scientific procedure. I will never again
commit such mistakes. Moreover, numerous other grant applications I submitted were
 also thoroughly examined
and were found to lack any misconduct; i.e., the findings of
 misconduct reflect an isolated mistake. 

I hasten to add that my research findings have never been in question. There will be no retractions based on
these findings. In fact, the grant that was at issue was not
 withdrawn and I am still receiving funding from that grant.

According to the HHS, “The purpose of HHS administrative actions is remedial. The appropriate administrative
action is commensurate with the seriousness of the
 misconduct, and the need to protect the health and safety of the
public, promote the
 integrity of the PHS supported research and research process, and conserve public funds”
42 CFR 93.408.

One important criteria that the ORI uses to determine sanctions focuses on impact: “Did the misconduct have
significant impact on the proposed or reported research record,
 research subjects, other researchers, institutions, or
the public health or welfare?” Id.. In
 my case, it was determined that there was no impact on the proposed or
reported research
 record, research subjects, other researchers, institutions, or the public health or welfare as
a result of my inappropriate actions.

I unquestionably committed serious errors in judgment. I regret these completely. I had no intention of misleading
the research community about our research studies in any
 way. My mistakes in judgment contained in the grant
applications had no material effect
 on the outcome of that research.

I would like to reassure everyone that the results of our research studies are sound and have never been called
into question. Even the one grant that was intensively reviewed
 during these proceedings was never revoked. The
ORI has requested that I enter into
 supervised research for the next two years. They have also requested that I not
serve on
 NIH grant review committees for these two years. These constraints are spelled out in a Voluntary
Settlement Agreement that I signed. While to some members of the public
 these sanctions appear mild, they are
consistent with the lack of material impact of my
 wrongdoings. Indeed, Dr. John Dahlberg, Deputy Director of the ORI,
stated “This
 administrative action is meant to assure that [my] research is accurately reported in grant
applications, manuscripts and public presentations, and is not intended to prevent [me]
 from pursuing a promising
career in science”.

I am utterly remorseful and penitent for my mistakes and wrongdoings. Finding treatments and cures for
Huntington’s disease and other neurodegenerative disorders is
 my driving passion. I hope that I can continue to
work and collaborate with others around
 the world, focusing on the future.


Paul J. Muchowski


Source: The Huntington’s Post

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