Topline data readout from Huntington’s disease clinical trials now expected by year end 2019
CAMBRIDGE, Mass., April 10, 2019 (GLOBE NEWSWIRE) — Wave Life Sciences Ltd. (NASDAQ: WVE), a clinical-stage genetic medicines company committed to delivering life-changing treatments for people battling devastating diseases, today provided an update on the timing of the topline data readout from its ongoing PRECISION-HD program, which consists of two global Phase 1b/2a clinical trials evaluating investigational therapies WVE-120101 and WVE-120102 for patients with Huntington’s disease (HD). The company now expects to report topline clinical data from the PRECISION-HD program by the end of the year. The reason for the revised timeline is operational, resulting from slower than anticipated patient enrollment because of the logistics of screening and scheduling across global sites. This update is not due to a preclinical or clinical safety finding and the PRECISION-HD clinical program remains blinded. The company expects the topline clinical data will include a summary of clinical safety results, the degree of mutant huntingtin protein lowering in cerebrospinal fluid (CSF) and the ratio of total huntingtin versus mutant huntingtin protein in CSF to assess wild-type huntingtin protein.
“When we initiated these exciting clinical trials to explore the potential of an allele-selective approach to treating Huntington’s disease, we set aggressive timelines for ourselves in recognition of the enormous need in the global Huntington’s disease community. While we are disappointed that enrollment is not as fast as we anticipated, we are pleased that patient and physician interest in the trials remains high,” said Michael Panzara, MD, MPH, Chief Medical Officer at Wave Life Sciences. “Like others in the community, we are focused on advancing these trials quickly and are eagerly looking forward to the first clinical results from the program.”
Source: Wave Life Sciences