Journal of Huntington’s Disease

We are delighted to announce the publication of Volume 4, Number 1 of the Journal of Huntington’s Disease (JHD).

This issue contains the review Epigenetic Mechanisms Involved in Huntington’s Disease Pathogenesis by Glajch and Sadri-Vakili that reviews a range of studies describing epigenetic changes in HD as well as several potential therapeutics that target aberrant epigenetic alterations in HD.

Also of interest is the research report Novel BAC Mouse Model of Huntington’s Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype by Wegrzynowicz et al, where they determine if a very large CAG repeat (>200) in full-length Htt elicits neurodegenerative phenotypes consistent with juvenile HD.

The full table of contents can be viewed below.

As a member of our research community, we would like to invite you to contribute your own articles to the Journal of Huntington’s Disease. JHD offers contributing authors many benefits, including rigorous peer review, speedy manuscript processing, online pre-publication and an Open Access option.

Follow us on Facebook for news related to JHD and Huntington’s disease research with insightful commentary by JHD Media Editor Dr. Joan Steffan. Join the discussion!

We are confident that the Journal of Huntington’s Disease will serve the HD community well in the coming years and decades and look forward to your contributions.

Kind regards,

Blair R. Leavitt, MD, CM
The University of British Columbia
Vancouver, BC, Canada

Leslie M. Thompson, PhD
University of California, Irvine
Irvine, CA, USA

Click on links below to access the articles.

Epigenetic Mechanisms Involved in Huntington’s Disease Pathogenesis
Kelly E. Glajch and Ghazaleh Sadri-Vakili

Research Reports
Novel BAC Mouse Model of Huntington’s Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype
Michal Wegrzynowicz, Terry Jo Bichell, Barbara D. Soares, Meredith K. Loth, Jennifer L. McGlothan, Fatima S. Alikhan, Kegang Hua, Jennifer M. Coughlin, Hunter K. Holt, Christopher S. Jetter, Susumu Mori, Martin G. Pomper, Alexander P. Osmand, Tomás R. Guilarte and Aaron B. Bowman

FDG μPET Fails to Detect a Disease-Specific Phenotype in Rats Transgenic for Huntington’s Disease – A 15 Months Follow-up Study
Ralf Reilmann, Veronika Lippross, Eva Hölzner, Fabian Gigengack, Stefan Bohlen, Harald Kugel, Michael Deppe, Nani Osada, M. Lücke, Olaf Riess, Huu Phuc Nguyen, Stephan von Hörsten, Klaus Schäfers, Michael Schäfers, Andreas H. Jacobs and Sven Hermann

Rating Apathy in Huntington’s Disease: Patients and Companions Agree
Sarah Mason and Roger A. Barker

Social Behaviour is Impaired in the R6/2 Mouse Model of Huntington’s Disease
Nigel I. Wood and A. Jennifer Morton

Relationship between Nutritional Status and the Severity of Huntington’s Disease. A Spanish Multicenter Dietary Intake Study
Esther Cubo, Jéssica Rivadeneyra, Diana Armesto, Natividad Mariscal, Asunción Martinez and Rafael J. Camara

Genetic Counselling for Predictive Testing in Huntington’s Disease in One Centre since 1993. Gender-Specific Aspects of Decision-Making
Larissa Arning, Constantin N. Witt, Jörg T. Epplen and Susanne Stemmler

Brief Report
Clinical and Molecular Features of Late Onset Huntington Disease in a Peruvian Cohort
Mario R. Cornejo-Olivas, Miguel A. Inca-Martinez, Keren Espinoza-Huertas, Diego Veliz-Otani, Mario R. Velit-Salazar, Victoria Marca, Olimpio Ortega, Ivan F. Cornejo-Herrera, Saul Lindo-Samanamud, Pamela Mora-Alferez and Pilar Mazzetti

16 Condivisioni