8th Plenary Meeting EHDN 2014 Barcelona: 19-21 settembre 2014 – Report

Annarita Bentivoglio* - Marina Frontali** Si è appena concluso l’ottavo meeting plenario del Network Europeo per la Malattia di Huntington. Oltre 900 partecipanti: l’incontro più numeroso...

Fatal cellular malfunction identified in Huntington’s disease

Researchers believe they have learned how mutations in the gene that causes Huntington’s disease kill brain cells, a finding that could open new opportunities...

‘Navigating’ the Huntington’s disease community towards crucial clinical trials

As scientists and drug companies expand the array of potential treatments for Huntington’s disease, the Huntington Study Group (HSG), the world’s largest HD clinical research network,...

Could molecular handcuffs lower the protein that causes Huntington’s disease?

Researchers got surprisingly lucky when looking for drug molecules to pull mutant huntingtin protein into a cellular garbage disposal machine Several approaches are being taken...

Scientists find a way to target the protein behind Huntington’s disease

A small molecule sends the problem protein to a system that digests it. Huntington's disease is caused by a dominant mutation, meaning that anyone who...

Researchers Identify Unique Brain Changes in People with Huntington’s Disease

The part of the brain that selectively degenerates in people with Huntington’s disease (HD), called the striatum, is almost entirely destroyed in the late...

Study focuses on repair and reversal of damage caused by Huntington’s...

UCLA research identifies a potential strategy that may lead to treatment for the disorde A new study examining the role that star-shaped brain cells called...

HUNTINGTON’S DISEASE GENETIC MUTATIONS EXPAND THROUGHOUT LIFE

The region of DNA associated with Huntington’s disease has been shown to grow throughout life and contribute towards disease progression. New research, published in EBioMedicine,...

As range of possible therapies grows, CHDI expands efforts to defeat...

his article is Part 1 of a two-part series. CHDI Foundation, Inc., the largest nonprofit effort aimed at developing therapies for Huntington’s disease, has expanded...

Miller School Study Could Lead to Neuroprotective Therapy for Huntington’s Disease

A laboratory study by University of Miami Miller School of Medicine researchers could lead to a new treatment strategy for Huntington’s disease, an incurable...

Achilles’ heel identified in several neurodegenerative diseases

A Stanford research team has identified an oddball way brain cells spread inflammation in several neurodegenerative diseases — and an approach that could counter...
New data on laquinimod from the Phase 2 LEGATO-HD study in Huntington’s disease will be presented at the International congress of Parkinson’s disease and movement disorders

New data on laquinimod from the Phase 2 LEGATO-HD study in...

Magnetic Resonance Spectroscopy Evaluation of Neuronal Integrity and Astrocytosis in a Phase 2 Study of Laquinimod as a Treatment for Huntington Disease (LEGATO-HD) Blair R....
Study gives clues to the origin of Huntington’s disease, and a new way to find drugs

Study gives clues to the origin of Huntington’s disease, and a...

The first signs of Huntington’s, an inherited disease that slowly deteriorates bodies and minds, don’t typically surface until middle age. But new findings suggest...

Details emerge of first Huntington’s disease gene therapy clinical trial

UniQure announces key details of its planned trial to assess the safety and ability of AMT-130 gene therapy to lower the problematic huntingtin protein...

EIP Pharma Initiates New Study with Neflamapimod for the Treatment of...

EIP Pharma, Inc., a CNS-focused therapeutics company, today announced the initiation of a new Phase 2 proof-of-concept study evaluating neflamapimod as a treatment for...

Sangamo Therapeutics Announces Nature Medicine Publication Detailing the Activity of Disease...

Jul. 1, 2019-- Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a genomic medicine company, today announced the publication of a manuscript describing the activity of allele-selective zinc finger...

Distinct clinical profiles of Huntington’s disease can be associated with two...

Cognitive-motor and psychiatric profiles of Huntington's disease show a different pattern of brain alterations The identification of specific neural signatures can help develop specific biomarkers...

BGU Scientists Duplicate Blood-Brain Barrier Outside the Body

​Scientists can't make a living copy of your brain outside your body. That's the stuff of science fiction. But in a new study, they...

A new molecular mechanism could explain the origins of the depressive...

About 40 % of the affected patients with Huntington’s disease –a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of...

My Huntington’s disease sister – and a hero who strives for...

Sharon Shaffer is my Huntington’s disease sister – and my hero. Afflicted with progressively worse HD symptoms the past 15 years, San Diego area resident...

uniQure Strengthens Intellectual Property Portfolio with Granted Patent Claims Covering AMT-130...

~ Issued Patents in the U.S. and EU Cover RNA Construct Specifically Designed to Target Highly Toxic Exon1 Protein ~ LEXINGTON, Mass. and AMSTERDAM, the Netherlands,...

Smartphone app can help diagnose a rare disease

Team of researchers at Kaunas University of Technology (KTU), Lithuania have created a mobile application, which helps recognise early symptoms of a rare Huntington’s...