Vaccinex, Inc. announced today that it has initiated a Phase 2 clinical trial to assess the safety, tolerability and efficacy of anti-semaphorin 4D antibody VX15/2503 (“VX15”) in Huntington’s disease (“HD”), a neurodegenerative genetic disorder that typically manifests in mid-adult life. This clinical trial, termed the “SIGNAL” clinical trial, will be performed with the assistance of the Huntington Study Group and is designed to evaluate VX15 antibody in up to 84 subjects with late-prodromal or early-manifest HD.
The SIGNAL trial is based on our prior research of neurodegenerative disease mechanisms, where we demonstrated in preclinical models that semaphorin 4D (“SEMA4D”) triggers activation of both microglia and astrocytes, the innate inflammatory cells of the central nervous system. The chronic activation of microglia and astrocytes has been implicated as a potentially important disease mechanism in HD, progressive multiple sclerosis (“MS”) and other neurodegenerative disorders. VX15 antibody is designed to block the functional activity of SEMA4D. The SIGNAL clinical trial will build upon preclinical studies in an animal model of HD and safety data from a Phase 1 dose-escalation clinical trial of VX15 in MS patients that we completed in November 2014.
Dr. Maurice Zauderer, President and Chief Executive Officer of Vaccinex, said: “We are very pleased to have initiated this clinical trial of our novel agent in a disease with such an important unmet need. The preclinical data generated with our antibody in an animal model of Huntington’s disease and our understanding of the mechanism of action suggest that this investigational agent may have the potential to delay the onset or slow the progression of HD.”
Source: Vaccinex Inc