A small difference was observed when the meta-analysis was restricted to studies from countries defined by the World Bank as high income, that used multiple methods of ascertainment, and that were conducted since 1980 (4.81%, 95% confidence interval 3.31% to 6.58%, n=11). This contrasts with the pooled result from three post 1980 studies using multiple methods of ascertainment from South Africa and Venezuela, defined by the World Bank as upper middle income, where the estimated mean proportion was 9.95%, (95% confidence interval 6.37% to 14.22%).
These results, which are expected to be more robust than those from a single study alone, may be helpful in estimating the proportion of JHD cases in a given population.
Key Words: Juvenile Huntington’s disease, prevalence, epidemiology
Source: PLoS Currents